Chemical and Biological Insights into Belactosin-based Proteasome Inhibitors

Author(s)	K. Saritha Rani, Rafiya Sultana, G. Pranitha
Country	India
Abstract	Belactosin is a naturally occurring peptide-derived secondary metabolite isolated from Streptomyces species and is recognized for its potent proteasome inhibitory activity. The proteasome plays a crucial role in intracellular protein degradation and regulation of cell cycle, apoptosis, and immune responses. Inhibition of the proteasome has emerged as a validated therapeutic strategy, particularly in cancer treatment. Belactosin A and its analogues possess a unique β-lactone moiety responsible for irreversible binding to the catalytic threonine residue of the proteasome. This paper presents a comprehensive review of belactosin, covering its discovery, chemical structure, biosynthesis, mechanism of action, biological activities, structure–activity relationships, pharmaceutical relevance, and future prospects. The study highlights belactosin as an important lead compound in natural product–based drug discovery.
Keywords	Belactosin, Proteasome Inhibitor, β-lactone, Streptomyces, Natural Products, Anticancer Agents
Published In	Conference / Special Issue (Volume 17 \| Issue 1) - One Day National Seminar on “Advances in Life Sciences for Diversity, Applications, and Human Welfare” (ALSDAHW-2025) (March 2026)
Published On	2026-03-16
DOI	https://doi.org/10.71097/IJSAT.ALSDAHW-2025.105

About IJSAT Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us	Message on WhatsApp	+91-9687-182-185	editor@ijsat.org

International Journal on Science and Technology