International Journal on Science and Technology

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Mapping of Epitopes in Potential Antigenic Proteins of Bovine Rhinotracheitis Virus using Immunoinformatics Tools

Author(s) Geethanjali Karli
Country India
Abstract Infectious Bovine Rhinotracheitis (IBR), caused by Bovine Herpesvirus type 1 (BHV-1), is a globally significant cattle disease that impacts both respiratory and reproductive health. As per the recommendations of World organization of animal Health, several PCR based assays and ELISA based assays were developed, however due to higher cost and complexity associated with the tests, regular surveillance programmes and on-site screening still remains a challenge. This current study aimed at proposing a potential antigen suitable for developing Antibody detection assays. Based on proteomics data, highly expressed proteins were shortlisted and analysed for various Bioinformatics and Immunoinformatics tools. B-cell epitopes from major IBRV envelope glycoproteins such as gB, gC, gD, gE and latency associated protein BICP0 were analysed using IEDB tools. Suitable epiptopes from each protein were utilized and developed a fusion protein suitable for detection of antibodies in both active infection as well as latent infection in the herds. Future experimental validation will confirm the utility of these epitopes for large-scale IBRV antibody detection and herd surveillance.
Keywords Infectious Bovine Rhinotracheitis, B-cell Epitope, Fusion Proteins, Peptide-based ELISA, Immunoinformatics
Published In Conference / Special Issue (Volume 17 | Issue 1) - One Day National Seminar on “Advances in Life Sciences for Diversity, Applications, and Human Welfare” (ALSDAHW-2025) (March 2026)
Published On 2026-03-16
DOI https://doi.org/10.71097/IJSAT.ALSDAHW-2025.111
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