International Journal on Science and Technology

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Volume 17 Issue 1
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Assessing the Role of Platelet Function in Adult Thrombocytopenia: A Hospital-Based Cross-Sectional Study

Author(s) Ms. Vandana Singh, Mr. Vipul Kumar, Mr. Ahmad Raza
Country India
Abstract Thrombocytopenia is a common hematological abnormality encountered in adult patients, particularly in hospitalized and critically ill populations. Conventional clinical practice relies predominantly on platelet count to assess bleeding risk;
However, increasing evidence suggests that platelet function plays a decisive role in determining hemostatic competence. Functional platelet abnormalities may lead to bleeding even when platelet counts are within clinically acceptable ranges. To evaluate platelet function in adult patients with thrombocytopenia using routine hematological parameters and peripheral blood smear examination, and to correlate functional platelet abnormalities with clinical bleeding
manifestations. A significant proportion of patients exhibited bleeding manifestations despite platelet counts above conventional transfusion thresholds. Elevated MPV and PDW values showed a statistically significant association with
bleeding risk. Peripheral smear examination revealed morphological abnormalities such as giant platelets and hypogranular platelets, which correlated with functional impairment. Platelet count alone demonstrated limited predictive value for bleeding risk.
Keywords Thrombocytopenia, Platelet Function, Mean Platelet Volume; Peripheral Blood Smear; Bleeding Risk; Adult Patients
Field Medical / Pharmacy
Published In Volume 17, Issue 1, January-March 2026
Published On 2026-02-07
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