International Journal on Science and Technology

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Thermophysical and Volumetric Properties of Memantine, Dorzolamide, and Moxifloxacin Hydrochlorides in Aqueous Solutions: A Comparative Study at Variable Temperatures and Pressures

Author(s) Dr. Ravinuthala Yesupadamu
Country India
Abstract This comprehensive study investigates the thermophysical and volumetric properties of three therapeutically significant pharmaceutical hydrochlorides—memantine hydrochloride (MEM), dorzolamide hydrochloride (DRZ), and moxifloxacin hydrochloride (MFX)—in aqueous solutions across variable temperature and pressure conditions. Experimental measurements of density (ρ), speed of sound (u), and refractive index (nD) were conducted at temperatures ranging from 298.15 K to 320.15 K under atmospheric pressure (0.1 MPa). From these primary measurements, derived thermophysical parameters including apparent molar volume (Vφ), limiting apparent molar volume (Vφ°), apparent molar isentropic compressibility (κφ), limiting apparent molar expansibility (Eφ°), Hepler's constant (∂²Vφ°/∂T²), molar refraction (RM), and hydration number (nh) were calculated. The results reveal dominant solute-solvent interactions characterized by hydrogen bonding, dipole-dipole, and dipole-induced dipole interactions. Hepler's thermodynamic relationship confirms structure-making behavior for all three hydrochlorides in aqueous media. The comparative analysis demonstrates distinct molecular interaction patterns attributable to structural differences among these pharmaceutical compounds, providing essential data for pharmaceutical formulation development and drug delivery optimization.
Keywords Thermophysical properties; Volumetric properties; Memantine hydrochloride; Dorzolamide hydrochloride; Moxifloxacin hydrochloride; Apparent molar volume; Isentropic compressibility; Solute-solvent interactions; Molecular dynamics.
Published In Volume 16, Issue 4, October-December 2025
Published On 2025-10-09
DOI https://doi.org/10.71097/IJSAT.v16.i4.10329
Short DOI https://doi.org/hbn7z4
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