International Journal on Science and Technology

E-ISSN: 2229-7677   •   Impact Factor: 9.88

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 17 Issue 1 January-March 2026 Submit your research before last 3 days of March to publish your research paper in the issue of January-March.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 17 Issue 1
January-March 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Therapeutic Potential of Vitex negundo for the Treatment of Polycystic Ovarian Disease (PCOD): A Review

Author(s) Dr. Sonali Periyasamy, Dr. Ravishankar Rajendran, Prof. Dr. Leelambigai Duraisamy, Prof. Dr. Abarna Selvaraj
Country India
Abstract Polycystic ovarian disease (PCOD), synonymous in most literature with polycystic ovary syndrome (PCOS), is a frequent endocrine and metabolic disorder among women of reproductive age. It is marked by chronic anovulation, clinical or biochemical hyperandrogenism, and characteristic polycystic ovarian morphology. Standard treatments such as combined oral contraceptives, insulin sensitizers, and ovulation-inducing agents largely offer symptomatic relief and may be limited by adverse effects, contraindications, or poor compliance. In parallel, there is growing interest in herbal agents that can target multiple aspects of PCOD pathophysiology with a favorable safety profile. Vitex negundo L. (family Lamiaceae), known as Nirgundi, is widely used in Ayurveda and folk medicine for gynecological disorders, pain, inflammation, and menstrual irregularities. This review summarizes current information on PCOD pathophysiology and examines pharmacognostic details, phytochemistry, pharmacological actions, and available preclinical and clinical evidence regarding Vitex negundo, with specific focus on mechanisms relevant to PCOD, such as anti-inflammatory, antioxidant, metabolic and potential endocrine-modulating effects. Experimental studies in animal models of PCOD indicate beneficial effects on ovarian morphology, estrous cyclicity, oxidative stress, and metabolic parameters. Human data remain preliminary and often confounded by polyherbal formulations. There is a strong mechanistic rationale for Vitex negundo as an adjunct in PCOD management; however, well-designed randomized controlled trials with standardized extracts are required before routine clinical use can be recommended.
Keywords Keywords: Vitex negundo, Nirgundi, PCOD, PCOS, herbal medicine, insulin resistance, hyperandrogenism, ovarian cysts
Field Medical / Pharmacy
Published In Volume 17, Issue 1, January-March 2026
Published On 2026-02-14
DOI https://doi.org/10.71097/IJSAT.v17.i1.10340
Short DOI https://doi.org/hbphzx
View / Download PDF File

Share this


CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJSAT DOI prefix is
10.71097/IJSAT

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 16 Isu 3Cover Page Vol 16 Isu 2Cover Page Vol 16 Isu 1

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJSAT
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us Message on WhatsApp +91-9687-182-185 editor@ijsat.org