International Journal on Science and Technology

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Designing and Characterization of Lithocholic Derived Poly(N-isopropylacrylamide) copolymer

Author(s) Ms. Yuvarani Manivannan, Dr. Karthi Rajendran, Dr. Kasthuri Jayapalan, Prof. Dr. Rajendiran Nagappan
Country India
Abstract In this study synthesis and characterization of poly (N-isopropyl acrylamide-co-methyl 3α-methacryloyl-lithocholan 24-oate) [poly(NIPAM-co-MELCAME)] was carried out by esterification of lithocholic acid methyl ester and subsequently copolymerized with N-isopropylacrylamide (NIPAM) through free-radical polymerization using AIBN as an initiator. The chemical structures of the monomer and copolymers were confirmed using 1H NMR, 13C NMR, and FT-IR spectroscopy. Gel Permeation Chromatography (GPC) analysis revealed a linear correlation between the monomer feed ratio and the copolymer molecular weight and the number-average molecular weight (Mn) increased systematically from 3,564 kg/mol to 9,199 kg/mol, with polydispersity indices (PDI) ranging between 1.03 and 1.57. Thermogravimetric analysis (TGA) demonstrated that the copolymers possess high thermal stability. The integration of the rigid, hydrophobic lithocholic acid moiety provides a tunable platform for developing bio-inspired smart materials. These findings suggest that Poly (NIPAM-co-MELCAME) copolymers hold significant potential for applications in responsive coatings and advanced materials engineering.
Keywords N-isopropylacrylamide, Lithocholic Acid, MELCAME, Free-radical polymerization, Thermal stability, GPC.
Field Chemistry
Published In Volume 17, Issue 1, January-March 2026
Published On 2026-02-25
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