International Journal on Science and Technology

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Design and Synthesis of Isoxazole Equipped Pyrazole Conjugated Benzimidazole Derivatives

Author(s) Dr. M. Mallesh . ., Dr. G. Satyanarayana Goud Gangari ., Dr. N. Venu Gopal . ., Dr. K. Thirupathaiah . .
Country India
Abstract Absract
Isoxazole-equipped pyrazole-conjugated benzimidazole derivatives indicates a class of heterocyclic compounds synthesized through multi-step process involving cyclocondensation reactions, often starting from benzimidazole precursors like 4-(1H-benzimidazol-2-yl)oxazol-2-amines, followed by incorporation of pyrazole and isoxazole moieties via Vilsmeier-Hack formylation. These derivatives are typically prepared by condensing arylhydrazines with aryl ketones to form pyrazole intermediates.
Keywords : Pharmacophore, Benzimidazole frame works, Vilsmeier-Hack formylation, antifungal activity, Thin Layer Chromatography.
Field Chemistry
Published In Volume 17, Issue 1, January-March 2026
Published On 2026-02-27
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