Dynamic Mechanical Stimulation Platform for Microphysiological Vascular Tissue Models

Author(s)	Samarth Patel
Country	United States
Abstract	Next-generation organ-on-chip systems require precise biomechanical control to replicate native tissue microenvironments under pathophysiological conditions. This paper presents a pneumatically actuated microfluidic platform that applies programmable compressive stresses to three-dimensional vascularized tissue constructs. Engineered microvascular networks cultured within the device exhibit pressure-dependent histological responses, including stress-induced cell death zones, exponential reactive oxygen species generation, and compromised barrier integrity. Finite element modeling validates the mechanical stress distribution patterns, correlating with experimental observations of vascular permeability and junctional protein disruption. This microphysiological system enables quantitative investigation of compression-induced vascular pathogenesis, offering a predictive tool for studying tumor microenvironment mechanics, hypertension-related vascular damage, and therapeutic safety evaluation of wearable medical devices. The platform establishes a foundation for integrating dynamic mechanical cues into vascularized organ-on-chip models for disease modeling and drug screening applications.
Field	Engineering
Published In	Volume 17, Issue 1, January-March 2026
Published On	2026-02-05
DOI	https://doi.org/10.71097/IJSAT.v17.i1.10424

About IJSAT Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us	Message on WhatsApp	+91-9687-182-185	editor@ijsat.org

International Journal on Science and Technology