International Journal on Science and Technology

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Analysis of Parkinson’s disease and its potential therapy with medicinal plants and phytochemicals – a review

Author(s) Ms. AYUSHI ., Dr. Kunal Singh
Country India
Abstract Parkinson’s disease is a chronic, progressive neurodegenerative disease in which, both, motor and non-motor symptoms show up. Loss of striatal dopaminergic neurons leads to the development of motor symptoms, which involves, resting tremor, bradykinesia, and, muscle rigidity. This disease is associated with multiple risk factors and mutations. Oxidative stress, formation of free radicles and multiple environmental toxins are some of the risk factors of this disease. ‘SNCA’ was identified as the first gene, responsible for Parkinson’s disease. Almost 5-10% PD patients suffers from a Parkinson’s disease, where autosomal dominant mutations occur in SNCA, LRRK2 and VPS35 genes and autosomal recessive mutations in PINK1, DJ-1 and Parkin genes, which cause this disease with high penetrance. However, most PD occurs by the combined action of common genetic variants with environmental factors. Abnormal aggregation of α-Synuclein and spread of pathology in different regions of Brain probably underlie the development and progression of Parkinson’s disease. This aggregated ‘α-Synuclein’ binds the proteasome and inhibits its activity. Ubiquitin accumulates in Lewy Bodies, and, Parkin and UCH-L1 also interact with the Ubiquitin proteasomal system, the resulting proteasomal dysfuction is thought to contribute in Parkinson’s disease. Many plants, such as – Mucuna puriens, Vicia faba L, Crocus sativus L, Curcuma longa, Ginkgo biloba, Gastrodia elata, Scutellaria baicalensis, Withania Somnifera, have been found to be potentially therapeutic against Parkinson’s disease. Many phytochemicals such as – Chrysin, Vanillin, Asiatic acid, Ferulic acid and Curcumin also have shown the potential to serve as therapeutic molecules against Parkinson’s disease.
Keywords SNCA, Alpha-Synuclein, Lewy bodies, Phytochemicals.
Field Biology > Medical / Physiology
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-04-14
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