International Journal on Science and Technology

E-ISSN: 2229-7677   •   Impact Factor: 9.88

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 17 Issue 2 April-June 2026 Submit your research before last 3 days of June to publish your research paper in the issue of April-June.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 17 Issue 2
April-June 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Evaluation of Antiulcer Activity of Rhynchosia beddomei

Author(s) B. Mamatha, K. Yamimi, T. Shanthipriya, B. Athulya
Country India
Abstract Peptic ulcer disease is a common gastrointestinal disorder caused by an imbalance between aggressive factors such as gastric acid secretion and the protective mechanisms of the gastric mucosa. Stress plays a crucial role in the development of gastric ulcers by increasing acid secretion, reducing mucosal blood flow, and inducing oxidative damage. Although several synthetic antiulcer drugs are available, their prolonged use is often associated with adverse effects, which has led to increased interest in herbal medicines as safer alternatives.

The present study was designed to evaluate the antiulcer activity of Rhynchosia beddomei using the cold- water immersion stress-induced ulcer model in Wistar albino rats. The plant material was extracted using the Soxhlet extraction method. The antiulcer activity of the extract was evaluated at two dose levels, 150 mg/kg and 300 mg/kg, administered orally. Ranitidine (10 mg/kg, p.o.) was used as the standard drug. Animals were divided into five groups comprising normal control, stress control, standard-treated, and test-treated groups.
Stress-induced ulcers were produced by subjecting the animals to cold water immersion. After the experimental procedure, gastric parameters such as gastric juice volume, pH, free acidity, total acidity, ulcer area, and percentage of ulcer protection were assessed. The extract of Rhynchosia beddomei showed a significant and dose-dependent reduction in gastric acidity and ulcer index, along with an increase in gastric pH when compared to the stress control group. The higher dose exhibited effects comparable to the standard drug.
The observed antiulcer activity may be attributed to the presence of phytocomponents with antioxidant and cytoprotective properties. The results suggest that Rhynchosia beddomei possesses significant antiulcer potential and supports its use as a natural gastroprotective agent.
Keywords Evaluation, Antiulcer Activity, Rhynchosia beddomei, Fabacea
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-04-01
View / Download PDF File

Share this


CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJSAT DOI prefix is
10.71097/IJSAT

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 17 Isu 1Cover Page Vol 16 Isu 3Cover Page Vol 16 Isu 2

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJSAT
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us Message on WhatsApp +91-9687-182-185 editor@ijsat.org