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Homocysteine level among sickle cell anemia patient with vascular occlusion Sudanese population

Author(s) Dr. May A. M Ashmaig, Prof. Fathelrahman M Hassan, Prof. Nadia M Madani, Prof. Amira H. A Arman
Country Sudan
Abstract Sickle cell disease (SCD) is an inherited hemoglobinopathy due to a homozygous mutation in the β-globin gene (HbSS), which gives rise to hemoglobin polymerization in a reduced oxygen environment, thereby producing sickled erythrocytes. Recurrent VOC are responsible for the development of primary vasculopathy involving peripheral, cerebral, as well as pulmonary circulations. Hyperhomocysteinemia, often combined with a deficiency of folate, is a recognized risk factor for vascular diseases.
The aim of this study was to investigate the relationship between the frequency of crises in SCD and the level of plasma homocysteine, to compare the level of Hcy in different hemoglobin genotypes, and to examine the CBC parameters.
Method:
One hundred Sickle Cell Disease patients and 100 healthy controls matched for age and sex were taken. Hemoglobin type was identified using electrophoresis, the value of the CBC was analyzed using the Mindray hematology analyzer, and the level of homocysteine was estimated using the ELISA method. Statistics were analyzed using the SPSS version 26 software.
Result:
There were no significant differences in blood parameters compared among different groups of age (p > 0.05). The concentration of homocysteine was found to be high in controls (HbAA) compared to patients (SCD) possessing varying hemoglobin
Conclusion
Plasma homocysteine levels were significantly lower in SCD patients compared to healthy controls, regardless of hemoglobin genotype. No association was observed between age and CBC parameters. These findings suggest that elevated homocysteine is unlikely to contribute to vaso-occlusive crises in SCD, highlighting the need for further studies to clarify its role in disease pathophysiology and vascular complications.
Keywords Electrophoresis, hemoglobinpathies
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-04-14
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