International Journal on Science and Technology

E-ISSN: 2229-7677   •   Impact Factor: 9.88

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 17 Issue 2 April-June 2026 Submit your research before last 3 days of June to publish your research paper in the issue of April-June.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 17 Issue 2
April-June 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Standardization and Multi-Targeted Therapeutic Profile of a 10-Ingredient Siddha Polyherbal Formulation: Scientific Validation of Urai Maathirai for Pediatric Care

Author(s) Dr Vishnupriya S, Dr Sudharsanan R S, Dr Sasikala C, Dr Valarmathi C
Country India
Abstract Background:
Siddha medicine offers a specialized therapeutic branch for pediatric care known as Balar Maruthuvam. Among its diverse pharmacopoeia, Urai Maathirai stands as a cornerstone polyherbal formulation, traditionally revered as a "pediatric panacea" for neonates and infants. Despite its widespread traditional use in treating Maandham (indigestion), Kanam (respiratory distress), and infantile colic, scientific documentation regarding its standardized preparation and multi-targeted pharmacological synergy remains sparse.
Objective:
The primary objective of this study is to provide a comprehensive scientific validation of a specific 10-ingredient Urai Maathirai formulation. This includes documenting the botanical authentication, the rigorous traditional purification protocol (Suddhi), and evaluating its therapeutic potential through its phytochemical profile and synergistic mechanisms.
Methods:
The ten herbal components—Zingiber officinale, Anacyclus pyrethrum, Myristica fragrans, Terminalia chebula, Ferula asafoetida, Glycyrrhiza glabra, Acorus calamus, Quercus infectoria, Piper longum, and Allium sativum—were authenticated and purified according to classical Siddha texts. Standardization was performed using High-Performance Thin-Layer Chromatography (HPTLC) to establish chemical finger-printing. Safety profiles were assessed based on established in-vivo acute toxicity parameters (OECD 423), with specific focus on the neutralization of \ beta-asarone via carbonization of Acorus calamus.
Results:
Phytochemical analysis confirmed the presence of bioactive markers including piperine, gingerols, and gallic acid, ensuring the formulation’s potency. The study identifies a "Bi-modal" therapeutic action where the formulation simultaneously addresses gastrointestinal dysbiosis and respiratory congestion. Acute toxicity data indicates the formulation is non-toxic (Category 5) at a dose of 2000 mg/kg, validating its safety for pediatric administration.
Conclusion:
The 10-drug Urai Maathirai is a scientifically robust, safe, and effective polyherbal matrix. The integration of traditional Suddhi processes ensures the mitigation of natural herbal toxicity while enhancing bioavailability. This research provides the necessary evidence-based framework for integrating Urai Maathirai into mainstream pediatric primary healthcare as a standardized Siddha intervention.
Keywords Siddha Medicine, Urai Maathirai, Balar Maruthuvam, Polyherbal Standardization, HPTLC Fingerprinting, Infantile Colic, Pediatric Safety.
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-05-08
View / Download PDF File

Share this


CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJSAT DOI prefix is
10.71097/IJSAT

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 17 Isu 1Cover Page Vol 16 Isu 3Cover Page Vol 16 Isu 2

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJSAT
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us Message on WhatsApp +91-9687-182-185 editor@ijsat.org