International Journal on Science and Technology

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The Antimicrobial Study of 3,3'-{1,3-phenylenebis[azanylylidene-(E)-methanylylidene]}di(quinolin-2-ol), with Ni(II), Cu(II), and Zn(II) transition metal ions

Author(s) Tushar S. Umasare
Country India
Abstract This study reports on the synthesis of novel Quinoline-based Schiff base, 3,3'-{1,3-phenylenebis[azanylylidene-(E)-methanylylidene]}di(quinolin-2-ol), by condensing 2-hydroxy quinoline-3-carbaldehyde with m-phenylenediamine in 1:2 molar ratio. The progress of the reactions and the purity of the synthesized compounds were monitored by TLC. The prepared Schiff base was then used to form metal complexes with Cu(II), Ni(II), and Zn(II). The synthesized compounds were characterized by solubility tests, melting point determination, UV-visible spectra, FT-IR spectra, magnetic moments, Molar conductivity measurement, AAS and elemental analyses. The low conductivity values of the compounds show they are non-electrolytic. The FT-IR data show there are O, N, N and O coordination sites on the ligand. The magnetic moments of the complexes of Cu(II) and Ni(II) are paramagnetic. The antimicrobial potential of the synthesized Schiff base and its metal complexes was evaluated by the disc diffusion method on agar medium against selected Gram-positive and Gram-negative bacterial strains, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, along with the fungal strain Candida albicans and Aspergillus niger, at the different concentrations. All prepared compounds had some antimicrobial activity against the above organisms, with the Cu-complex having the greatest one with an inhibition zone ranging from 15 to 23 mm.
Keywords Quinoline, Schiff base, Metal complexes, Antimicrobial Activity
Field Chemistry
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-05-17
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