International Journal on Science and Technology

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Evaluation of Pharmacological Potential of Punica granatum Leaves Using in Silico Approaches

Author(s) Bhakti Prakash Jadhav, Umme Roman, Dr. Abhijit Pohekar
Country India
Abstract The present study was carried out to investigate the phytochemical constituents and pharmacological potential of Punica granatum leaves using a network pharmacology approach. Punica granatum, commonly known as pomegranate or Dalimb, is a medicinal plant widely used in traditional systems of medicine due to its therapeutic properties. Fresh leaves were collected, shade dried, powdered, and extracted using suitable solvents for phytochemical analysis. Preliminary phytochemical screening revealed the presence of important bioactive compounds such as flavonoids, tannins, alkaloids, glycosides, saponins, phenolic compounds, and terpenoids. These phytoconstituents are associated with various pharmacological activities including antioxidant, anti-inflammatory, antimicrobial, antidiabetic, hepatoprotective, and anticancer effects. Network pharmacology analysis was performed using bioinformatics databases and software tools such as SwissTargetPrediction, GeneCards, STITCH, and Cytoscape to identify compound-target interactions and biological pathways. The study suggested that the therapeutic effects of Punica granatum leaves are mediated through multi-component and multi-target mechanisms. The findings support the traditional medicinal uses of the plant and indicate its potential for future drug discovery and development of herbal therapeutic agents
Punica granatum Leaves → Phytochemical Screening → Target Prediction → Network Analysis → Pathway Enrichment → Therapeutic Mechanism
Keywords Punica granatum, Network Pharmacology, Phytoconstituents, Bioactive Compounds, ADME Analysis, Medicinal Plants, Systems Pharmacology
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-05-28
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