International Journal on Science and Technology

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Volume 17 Issue 2
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Network Pharmacology and Phytochemical Investigation of Azadirachta Indica Leaf

Author(s) Avinash Manohar Bakle, Umme Roman Shaikh
Country India
Abstract Because of its many therapeutic uses, Azadirachta indica, or neem, is a medicinally significant plant that is frequently utilized in conventional healthcare systems. Using a network pharmacology technique, the current study was carried out to assess the phytochemical components and pharmacological importance of neem leaves. Fresh neem leaves were gathered, shade-dried, ground into a powder, and then extracted using the maceration process with either methanol or ethanol. A preliminary phytochemical screening was performed on the produced extracts in order to identify significant secondary metabolites. Alkaloids, flavonoids, tannins, saponins, glycosides, phenolic compounds, and terpenoids were all found, according to qualitative examination. These phytochemicals, which are well-known for their biological properties, greatly enhance neem's therapeutic potential in both conventional and contemporary uses across the globe. Quercetin, rutin, hyperoside, quercitrin, nimbolide, azadirachtin, and nimbaflavone are among the significant phytoconstituents found in neem leaves that were chosen for additional pharmacological analysis. These compounds' pharmacokinetic characteristics and drug-likeness were examined utilizing common scientific databases like PubChem, IMPPAT, and TCMSP. The results showed that neem phytochemicals had potent anti-inflammatory, immunomodulatory, anticancer, antioxidant, and antibacterial properties. These substances interact with several biological targets and disease-related signaling pathways, suggesting a multi-target mechanism of action, according to network pharmacology analysis. Quercetin and rutin showed very encouraging drug-likeness ratings and pharmacological potential among the assessed phytoconstituents. The study demonstrates the value of network pharmacology in herbal drug development and therapeutic research while providing scientific validation for the traditional medicinal significance of neem.
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-05-28
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