International Journal on Science and Technology

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Deciphering the Therapeutic Potential of Ajuga bracteosa Whole Plant Phytoconstituents Using Network Pharmacology

Author(s) Sanjivani Gawali, Prof. Umme Roman Shaikh
Country India
Abstract Ajuga bracteosa Wall. ex Benth. is an important medicinal herb belonging to the family Lamiaceae and has been extensively utilized in traditional systems of medicine for the management of inflammatory disorders, diabetes, infections, liver diseases, respiratory disorders, and neurological conditions. The plant contains diverse phytoconstituents including flavonoids, diterpenoids, phytoecdysteroids, glycosides, phenolic compounds, sterols, and tannins that contribute to its broad pharmacological activities. Recent advances in computational biology and systems pharmacology have enabled researchers to investigate the multitarget therapeutic mechanisms of medicinal plants through network pharmacology approaches. Unlike the conventional “one drug-one target” concept, network pharmacology explains the synergistic interactions between multiple compounds and multiple molecular targets involved in complex diseases.
The present review summarizes the ethnomedicinal importance, taxonomy, morphology, phytochemical profile, pharmacological activities, toxicity studies, and network pharmacology-based therapeutic potential of Ajuga bracteosa. Major bioactive compounds identified from the plant include luteolin, apigenin, quercetin, β-sitosterol, stigmasterol, ajugapitin, cerotic acid, ceryl alcohol, and phytoecdysteroids such as 20-hydroxyecdysone. Computational prediction studies have demonstrated interactions of these phytoconstituents with multiple biological targets associated with inflammation, oxidative stress, apoptosis, metabolic regulation, and cancer progression. Hub genes such
as AKT1, TNF, IL6, and MAPK signaling proteins have been identified as key mediators in the pharmacological actions of the plant.
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-05-28
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