International Journal on Science and Technology

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Call for Paper Volume 17 Issue 2 April-June 2026 Submit your research before last 3 days of June to publish your research paper in the issue of April-June.
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In-Silico and Phytochemical Evaluation of Neem Bark (Azadirachta indica): A Comprehensive Review

Author(s) Omkar Balaji Kamble, Umme Roman Shaikh
Country India
Abstract This research looked into the chemical makeup and healing properties of Neem bark (Azadirachta indica), combining lab tests with computer-based drug analysis. Because of its active natural compounds, Neem bark has long been part of traditional medicine. For this work, the bark was gathered fresh, washed thoroughly, left to dry in the open air, ground into powder, then soaked in solvent at room temperature. After extraction, the liquid underwent basic testing to detect key plant-derived chemicals. Tests showed the plant holds active substances like alkaloids, flavonoids, alongside glycosides. Among them, chemicals such as Nimbiol and Sugiol stood out during deeper examination. Tools like Molsoft and SwissADME helped assess how closely these fit typical medicine traits. Outcomes pointed toward solid structural features, along with suitable ratings for becoming drugs. Most results from Protox-II showed low risk across key toxic effects like liver harm, heart issues, DNA changes, cancer links, cell damage - pointing toward a generally safe profile. Alongside this, methods using computer models and network-based pharmacology helped explore how Neem bark chemicals might work in medicine. Evidence points to several active roles these natural substances could play in treatment strategies. What stands out is that science now backs long-standing uses of Neem bark in healing practices. Tools such as phytochemical checks paired with digital simulations prove helpful when studying plant-based remedies and their biological actions.
Keywords Neem bark, Azadirachta indica, phytochemical screening, in-silico study, network pharmacology, drug-likeness analysis, Protox-II, SwissADME, phytoconstituents, computational pharmacology.
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-05-28
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