International Journal on Science and Technology

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In Silico Network Pharmacology Analysis of Bioactive Compounds from Punica granatum Pericarp

Author(s) Bhakti Atmaram Chitrak, Umme Roman
Country India
Abstract Punica granatum, commonly known as pomegranate, is an important medicinal plant widely used in traditional systems of medicine due to its rich phytochemical composition and therapeutic potential. The pericarp (fruit peel) of the plant contains several biologically active phytoconstituents such as ellagic acid, gallic acid, quercetin, kaempferol, luteolin, punicalagin, and ursolic acid, which are reported to possess antioxidant, anti-inflammatory, antimicrobial, anticancer, and cardioprotective activities. koThe present review article focuses on the network pharmacology-based evaluation of phytoconstituents present in the pericarp of Punica granatum. Network pharmacology is an emerging computational approach that helps in understanding the multi-component and multi-target therapeutic mechanisms of herbal medicines. In the present study, phytochemical information was collected from published scientific literature and databases such as Dr. Duke’s Database and IMPPAT Database. Drug-likeness and pharmacokinetic properties of selected compounds were analyzed using MolSoft and SwissADME, while toxicity prediction was performed using Protox-II. The analysis suggested that major phytoconstituents of pomegranate pericarp exhibit favorable pharmacological properties and may interact with multiple biological targets associated with inflammation, oxidative stress, immune regulation, and cancer-related pathways. The study highlights the significance of network pharmacology in validating the traditional medicinal importance of pomegranate and provides scientific support for its future application in herbal drug discovery and development.
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-05-28
DOI https://doi.org/10.71097/IJSAT.v17.i2.11194
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