International Journal on Science and Technology

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Utilizing Box-Behken Design to Prepare Solid Lipid Nanoparticles Loaded with Moxifloxacin

Author(s) P. Venkatesh, Dr. Gopinadh Vuyyala, Dr. D. Varun, Nimma Vijaya Rekha, S.K. Godasu
Country India
Abstract In order to create a solid lipid nanoparticle (SLN) containing lomifloxacin, the current work employed response surface methods to investigate the link between design parameters and experimental results. A Box-Behnken design was constructed using solid lipid (X1), surfactant (X2), and drug/lipid ratio (X3) level as independent factors. SLN was successfully created using a modified melt-emulsion ultrasonication and low temperature solidification technique with glyceryl monostearate as the solid lipid and poloxamer 188 as the surfactant. The dependent variables were turbidity, drug loading (DL), and entrapment efficiency (EE). Examined were SLN's morphology, particle size, zeta potential, EE, DL, and drug release behavior. As a result, the suggested nanoparticles were nearly spherical and had a mean particle size of 248 nm. The particle size exhibited a zeta potential of -8.74 mV and a polydispersity index of 0.277 ± 0.058. EE (%) and DL (%) might reach as high as 83.29% ± 1.23% and 10.11% ± 2.02%, respectively. In vitro release experiments showed that moxifloxacin was released from SLN for up to 48 hours following an initial burst release. The release kinetics of the enhanced formulation most closely resembled the Peppas-Korsmeyer model. These results indicated that the moxifloxacin-loaded SLN might be utilized as a delivery system with improved drug entrapment efficacy and controlled drug release.
Keywords Box-Behken Design, Moxifloxacin, Solid Lipid Nano Particles, Ocular Delivery
Field Medical / Pharmacy
Published In Volume 17, Issue 2, April-June 2026
Published On 2026-06-09
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