International Journal on Science and Technology

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The Emerging Role of Micro RNAs in Human Disease: A Review of Complete Understanding of Mechanism, Functions and Implications

Author(s) Shailendra, Kamal Singh Bani, Dr. Nakul Gupta, Vikas Kumar, Shiv Sagar, Swati
Country India
Abstract MicroRNAs (miRNAs) are pivotal regulators of gene expression, influencing a myriad of biological processes such as development, cell differentiation, and stress responses. These small, non-coding RNA molecules exert their effects by binding to complementary sequences on target messenger RNAs (mRNAs), leading to mRNA degradation or inhibition of translation. Recent advancements have illuminated the complexity of miRNA networks, revealing their role in orchestrating not only individual gene regulation but also broader signaling pathways. Dysregulation of miRNAs is increasingly recognized as a contributing factor in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. This project aims to elucidate the mechanisms by which miRNAs regulate cellular functions and their potential implications in disease pathology. By integrating bioinformatics analyses and experimental validation, we seek to identify key miRNA-mRNA interactions that could serve as therapeutic targets or biomarkers for precision medicine. Understanding these networks could pave the way for innovative approaches to diagnosis and treatment.
Keywords MicroRNA , singling, Dysregulation, Bioinformatics, Cell – differentiation
Field Biology > Genetics / Molecular
Published In Volume 16, Issue 2, April-June 2025
Published On 2025-05-17
DOI https://doi.org/10.71097/IJSAT.v16.i2.4780
Short DOI https://doi.org/g9kfzs
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