International Journal on Science and Technology

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Revisiting Parkinson’s Disease Management: A Comprehensive Review of Herbal Approaches and Modern Delivery Strategies

Author(s) Shivaraj Hooli, Kishori P Sutar, Sankalp S. Sammasagi
Country India
Abstract Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor and non-motor symptoms. Current pharmacological treatments provide symptomatic relief but are often limited by side effects and do not prevent disease progression. As a result, there is increasing interest in herbal medicines as potential alternatives or complementary therapies for PD. Various plant-based compounds such as Mucuna pruriens, Withania somnifera, Curcuma longa, and Panax ginseng have shown neuroprotective effects through mechanisms like antioxidant activity, anti-inflammatory responses, and support of dopaminergic function. This review provides an overview of PD pathophysiology and current therapeutic strategies, followed by a discussion on the biological actions of key herbal agents. Recent advancements in herbal drug formulations, including nanoformulations and transdermal systems, are also presented. Evidence from both preclinical and clinical studies on the effectiveness and safety of herbal treatments is evaluated, along with information on herb-drug interactions. The review also highlights ongoing challenges in standardization, dosage regulation, and research gaps, while pointing toward future possibilities for integrating herbal and conventional approaches in PD management.
Keywords Parkinson’s Disease, Herbal Medicine, Neuroprotection, Phytotherapy
Field Medical / Pharmacy
Published In Volume 16, Issue 2, April-June 2025
Published On 2025-05-21
DOI https://doi.org/10.71097/IJSAT.v16.i2.5077
Short DOI https://doi.org/g9mpbd
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