International Journal on Science and Technology

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“Multitargeted Approaches in Cancer Therapy Using Nitrogen-Embedded Compounds”

Author(s) Gaitonde Apeksha Govind, Shankar G. Alegaon, Niteen R. Sutar
Country India
Abstract Cancer continues to be one of the most widespread and life-threatening diseases globally, driving the pursuit of more effective and less harmful treatment strategies. Among the promising approaches, nitrogen-containing heterocyclic compounds—such as quinoline, quinazoline, and pyrimidine—have received considerable attention for their diverse anticancer properties. These molecular frameworks play a critical role in targeted cancer therapies due to their capacity to inhibit essential enzymes and pathways like EGFR, PARP, PI3K, and topoisomerases. This overview emphasizes the structure-activity relationships (SAR), therapeutic mechanisms, and recent progress in the design of nitrogen-based anticancer agents. It discusses a range of compounds that exhibit strong activity against cancers such as those affecting the breast, lungs, liver, and colon, supported by molecular docking and in vivo studies that confirm their target-binding potential and therapeutic efficacy. Overall, this document offers valuable insights for researchers involved in the discovery and development of innovative cancer therapies utilizing nitrogen-rich molecular scaffolds.
Keywords Nitrogen-containing scaffolds, Quinoline, Quinazoline, Pyrimidine, Cancer therapy, EGFR inhibition, Molecular docking, SAR, Targeted therapy, Anticancer agent
Field Medical / Pharmacy
Published In Volume 16, Issue 2, April-June 2025
Published On 2025-05-21
DOI https://doi.org/10.71097/IJSAT.v16.i2.5386
Short DOI https://doi.org/g9mq8g
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