International Journal on Science and Technology

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Formulation, Evaluation, And Optimization Of Orally Disintegrating Tablets Containing Lipid-Lowering Drug

Author(s) Kartik Patel, Bhavna Patel, Jashoda Prajapati
Country India
Abstract ABSTRACT: Objective: To formulate and evaluate Orally Disintegrating Tablets containing Ezetimibe by direct compression method. Additionally, formulation optimization utilizing the Factorial design method. To increase patient compliance, the tablet is made with natural superdisintegrants including Emcosoy, Chia seed Mucilage, Guar Gum, and other appropriate excipients for the formulation. Experimental work: The Orally Disintegrating Tablet of Ezetimibe is formulated using direct compression method along with different excipients. Disintegrating agents are the main components in the formulation. To achieve the necessary disintegration time for an oral disintegrating tablet, they are utilized in a specific quantity. 32 factorial design is used to optimize the tablet formulation. Pre-post compression parameters were used to evaluate each formulation. Result: The Orally Disintegrating Tablet of Ezetimibe formulation containing 20 mg (10%) of Emcosoy (Soy Polysaccharides) exhibit excellent disintegration time of 29.20 seconds. The resulted formulation complies with the desired tablet parameters and all the tests needed. The hardness of tablet was found to be 3.30 kg/cm2 , and the dissolution result complied with a release of 99.99 % of the drug within 30 minutes. Conclusions: The studies indicate that Ezetimibe Orally Disintegrating Tablet was effective using Emcosoy as natural superdisintegrant in proving drug release with acceptable disintegration time.
Keywords Direct compression, natural superdisintegrant, orally disintegrating tablet, 3 2 factorial design, Ezetimibe, disintegration time.
Field Medical / Pharmacy
Published In Volume 16, Issue 2, April-June 2025
Published On 2025-06-18
DOI https://doi.org/10.71097/IJSAT.v16.i2.6221
Short DOI https://doi.org/g9qqzn
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