International Journal on Science and Technology

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ANTI DIABETIC ACTIVITY OF PIPER BETEL LINN IN ALLOXAN INDDUCED FEMALE WISTAR RATS

Author(s) P.VIJAY KUMAR, NEMALI.SEKHAR, V.PRANAY KUMAR, B.TANVI CHOWDARY
Country India
Abstract Piper betel Linn. (family Piperaceae), has a long history spanning more than two millennia, since plants are abundant sources of pharmaceuticals, many cultures worldwide employ them directly as remedies. An increase in blood glucose levels above 200 mg/dL is known as hyperglycaemia, and it is one of the early signs of diabetes mellitus. Literature study and research methods have shown hyperglycaemia can be tackled effectively by piper betel linn. Flavonoids are among the phytochemical substances found in piper betel leaves. By scavenging hydroxyl radicals that harm the pancreatic β cells, these antioxidants can maximize the synthesis of insulin. It has been demonstrated empirically that the flavonoid content of betel leaves can reduce blood glucose levels and treat diabetes mellitus. An evaluation of the anti-hyper glycaemic qualities of the piper betel leaf ethanol extract fraction was carried out. In rats with experimental diabetes produced by alloxan, the current study sought to assess the anti-diabetic potential of Piper betel leaves. When Piper betel leaf extract was given orally to diabetic rats for 25 days, the altered levels of biochemical markers like blood glucose, LDL, VLDL, cholesterol, and triglycerides were dramatically restored. Six Female Wistar rats was split up into four groups: group 1 received normal saline, group 2 received diabetic control, group 3 received a standard oral medication for diabetes, and group 4 received ethanolic extract of Piper betle. No evidence of toxicity upon autopsy was found, no enlargement of liver, kidney, spleen .in conclusion piper betel linn was more effective and safer in diabetic control Wistar rats compared to standard drug. Piper betle linn extracts demonstrated anti-diabetic and antioxidant effects in alloxan-induced diabetic Wistar rats, supporting its traditional use and potential as a therapeutic agent for managing diabetes mellitus.
Keywords Piper betle leaves, hyperglycaemia, Anti diabetic, Antioxidants, Alloxan induced diabetes, Beta cells, Toxicity studies
Field Medical / Pharmacy
Published In Volume 16, Issue 3, July-September 2025
Published On 2025-07-02
DOI https://doi.org/10.71097/IJSAT.v16.i3.6327
Short DOI https://doi.org/g9r8g7
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