Plant-Based Vaginal Suppository for Vulvovaginal Candidiasis – A Natural Remedy Revisited

Author(s)	Ms. Archana Nathu Wadile, Ms. Sunaina S. Dhangar
Country	India
Abstract	• Background: Rising antifungal resistance and side effects of conventional VVC treatments necessitate plant-based alternatives. • Objective: Develop and optimize herbal vaginal suppositories using neem, cinnamon, eucalyptus, and ginger via DOE, characterize actives (HPTLC), and evaluate antifungal efficacy. • Methods: o DOE-guided formulation with varying plant extract ratios. o HPTLC fingerprinting of bioactive compounds. o Agar dilution and MIC assays against Candida albicans. • Results: o Optimal suppository composition (e.g., 20% neem, 15% cinnamon) showed synergistic antifungal effects. o HPTLC confirmed key actives (azadirachtin, cinnamaldehyde). o Suppositories exhibited comparable efficacy to clotrimazole (p<0.05). • Conclusion: Plant-based suppositories are a promising, natural alternative for VVC, warranting further clinical validation
Keywords	Plant-based vaginal suppositories, herbal extracts, antifungal efficacy, formulation optimization, vulvovaginal candidiasis,
Field	Medical / Pharmacy
Published In	Volume 16, Issue 3, July-September 2025
Published On	2025-07-12
DOI	https://doi.org/10.71097/IJSAT.v16.i3.6685
Short DOI	https://doi.org/g9s9wg

About IJSAT Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us	Message on WhatsApp	+91-9687-182-185	editor@ijsat.org

International Journal on Science and Technology