Design and Synthesis of Thiazole Derivatives as Novel Anti-oxidant Agents

Author(s)	Dr. Ampati Srinivas, Mr. Jangam Tharun Kumar, Ms. Penta Ashwitha, Ms. Ramavath Vaishnavi, Ms. Danthuri Sindhuja, Ms. Mekangadda Anusha, Ms. Bandari Sadwika, Ms. Kathi Nandini
Country	India
Abstract	A straightforward and effective methodology was established for the synthesis of 2-(2-arylidenehydrazinyl)-4,5-diphenylthiazoles (Va-Vg) through the reaction of 1,3-diphenyl-propane-1,3-dione with suitable aromatic aldehydes to produce 2-methoxy-4,5-dimethylthiazole, which is subsequently reacted with hydrazine hydrate and further treated with diverse aromatic aldehydes. The synthesized compounds were structurally verified employing IR, NMR, and mass spectrometry. Furthermore, investigations into antioxidant activity were performed, demonstrating the promising bioactivity of the synthesized thiazole derivatives. Compound Ve exhibited the highest antioxidant activity in comparison to the standard, with an IC50 value of 23.71, followed by Vd with an IC50 value of 32.11. Compounds Vc and Vf demonstrated moderate antioxidant activity, with IC50 values of 47.3 and 51.6, respectively.
Keywords	Thiazole derivatives, IR, NMR, Mass, Anti-Oxidant, IC50
Field	Medical / Pharmacy
Published In	Volume 16, Issue 3, July-September 2025
Published On	2025-07-11
DOI	https://doi.org/10.71097/IJSAT.v16.i3.6975
Short DOI	https://doi.org/g9s9vw

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