Preparation and Evaluation of Ibuprofen Syrup

Author(s)	Dr. Aparna Chiluka, Mr. Abhinay Varma Vegesna, Ms. Lavanya V, Mr. Brahmam Panga, Ms. Shravya Yelganamoni, Ms. Harshini Shyamapanth
Country	India
Abstract	The aim of the study was to formulate and evaluate ibuprofen syrup using the cosolvency technique. The cosolvency technique involves combining various water miscible solvents at low concentrations to enhance drug solubility while minimizing solvent toxicity and ensuring formulation safety. Different formulations (F1, F2, F3) were prepared using combinations of cosolvents like propylene glycol, polyethylene glycol 400, glycerol, and ethanol. The prepared formulations were evaluated for their organoleptic properties, pH, viscosity, and drug content. Formulation F1 showed the highest drug content, making it the most effective and stable formulation. The study confirms cosolvency as a practical and scalable method for producing liquid dosage forms of poorly soluble drugs.
Keywords	Cosolvency, Solubility, Syrup.
Field	Medical / Pharmacy
Published In	Volume 16, Issue 3, July-September 2025
Published On	2025-08-03
DOI	https://doi.org/10.71097/IJSAT.v16.i3.7481
Short DOI	https://doi.org/g9vzdn

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