Advances in Dendritic Cell Targeted Delivery System

C.S. Parameswari; Manapati Manasa

doi:10.71097/IJSAT.v16.i4.8985

Advances in Dendritic Cell Targeted Delivery System

Author(s)	Dr. C.S. Parameswari, Ms. Manapati Manasa
Country	India
Abstract	Dendritic cells (DCs) are highly effective antigen-presenting cells (APCs) that play a central role in coordinating both innate and adaptive immune responses. Their activity can be modulated in several ways to strengthen antitumor immunity. Within the tumor microenvironment (TME), DCs initiate antigen-specific T cell responses by processing and presenting tumor-associated antigens (TAAs), while tumor cells counteract this by releasing cytokines, metabolites, and other factors that suppress DC recruitment and function. Multiple DC subsets are present in tumor tissues, each with distinct roles, and understanding these subpopulations provides valuable insight into the potential effectiveness of tumor immunotherapies. Exosomes are nanosized vesicles, typically 30–120 nm in diameter, secreted by all cell types including dendritic cells. They serve key roles in cell-to-cell communication and tissue interaction within the body. Due to their functional properties, exosomes hold promise as biomarkers and therapeutic tools for disease diagnosis, monitoring treatment outcomes, and prognosis. For clinical application on a large scale, essential requirements include efficient, rapid, and low-cost methods that yield high-purity exosomes with reliable characterization, safety, and therapeutic potential. Depending on the sample type, stress conditions, and quantity needed, exosomes can be extracted from diverse sources such as body fluids, solid tissues, or cultured cells using multiple isolation techniques. This review examines current advances in exosome isolation and characterization, highlighting their respective strengths and limitations. Such insights support the selection of suitable separation approaches for different biological samples and promote the integration of exosomes into translational and clinical research, particularly in oncology.
Keywords	Dendritic cells (DCs), antigen presenting cells (APCs), tumor microenvironment (TME), tumor associated antigens (TAAs), tumor immunotherapy, innate immunity, adaptive immunity, cell-to-cell communication, exosomes, nanosized vesicles, biomarkers, therapeutic tools, disease diagnosis, prognosis, Oncology.
Field	Medical / Pharmacy
Published In	Volume 16, Issue 4, October-December 2025
Published On	2025-11-23
DOI	https://doi.org/10.71097/IJSAT.v16.i4.8985
Short DOI	https://doi.org/hbb8hg

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Advances in Dendritic Cell Targeted Delivery System

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