‘CHG Disinfectants in the Medical Device Industry: A Comprehensive Review of Efficacy, Safety and Regulatory Compliance’

Author(s)	Jani Hetal, Kothwala Dr. Deveshkumar
Country	India
Abstract	Chlorhexidine Gluconate (CHG) is a synthetic cationic bisbiguanide compound extensively used in healthcare for its broad-spectrum antimicrobial activity. It disrupts microbial cell membranes and provides long-lasting residual action, making it highly effective in both clinical and manufacturing environments. In the context of medical device production, maintaining sterility is critical, as contamination can lead to healthcare-associated infections (HAIs), product recalls, or regulatory non-compliance. This makes CHG especially valuable in cleanroom settings, equipment disinfection, and personnel hygiene protocols. Despite widespread usage, a comprehensive review focused on CHG's specific role in the medical device industry—covering its mechanism, spectrum, material compatibility, regulatory considerations, and emerging resistance issues—is limited. This review fills that gap by evaluating CHG’s performance across all stages of device production and highlights its indispensable role in reducing infection risks, ensuring regulatory compliance, and enhancing patient safety.
Field	Medical / Pharmacy
Published In	Volume 16, Issue 4, October-December 2025
Published On	2025-11-09

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