International Journal on Science and Technology

E-ISSN: 2229-7677   •   Impact Factor: 9.88

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 16 Issue 4 October-December 2025 Submit your research before last 3 days of December to publish your research paper in the issue of October-December.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 16 Issue 4
October-December 2025

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Microbial Metabolites as Neuroprotective Agents Against Heavy Metal Exposure

Author(s) Ganiyat Opemipo Sanni, Oghenefejiro Oro Ighogboja, Ebizimo Preyor, Mulikat Adeola Orenolu-Qamardeen
Country United States
Abstract Heavy metal exposure poses a significant threat to neurological health, contributing to cognitive dysfunction, neuroinflammation, and neurodegenerative disorders. In recent years, growing evidence has revealed the critical role of the gut microbiome and its metabolites in protecting the nervous system from toxic insults. Microbial metabolites such as short-chain fatty acids (SCFAs), indoles, bile acid derivatives, and neurotransmitter-like compounds act as biochemical mediators that maintain gut-brain communication and counteract the neurotoxic effects of metals like lead (Pb), cadmium (Cd), mercury (Hg), and arsenic (As). These metabolites influence neuroprotection by modulating oxidative stress, inflammation, mitochondrial function, and blood–brain barrier integrity. This paper explores how gut-derived metabolites mitigate heavy-metal-induced neurotoxicity through antioxidant defense mechanisms, regulation of microglial activity, and stabilization of neuronal signaling pathways. It further examines how dysbiosis, resulting from chronic metal exposure, disrupts the production of key neuroprotective metabolites and amplifies neuronal injury. Emerging therapeutic approaches such as microbiome modulation, dietary interventions, and probiotic supplementation are also discussed as promising strategies to enhance endogenous metabolite production and restore neuroprotective balance. Understanding the interplay between microbial metabolites and metal neurotoxicity provides a foundation for novel microbiome-based therapeutics that target the gut–brain axis to prevent or alleviate metal-induced neurological damage.
Keywords Gut microbiome, Microbial metabolites, Heavy metals
Field Biology > Medical / Physiology
Published In Volume 16, Issue 4, October-December 2025
Published On 2025-11-22
DOI https://doi.org/10.71097/IJSAT.v16.i4.9560
Short DOI https://doi.org/hbb8ft
View / Download PDF File

Share this


CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJSAT DOI prefix is
10.71097/IJSAT

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 16 Isu 3Cover Page Vol 16 Isu 2Cover Page Vol 16 Isu 1

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJSAT
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us Message on WhatsApp +91-9687-182-185 editor@ijsat.org