International Journal on Science and Technology

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Method Development and Validation for the Simultaneous Estimation of Telmisartan and Azelnidipine in Bulk and Tablet Dosage Form by using HPLC

Author(s) Nagi Reddy. N, Swetha. B, Ravindar Bairam, Manjunath SY, Gorantla Nagamallika, Balakrishnaiah. P.
Country India
Abstract We established a simple, accurate, and exact approach to estimate the simultaneous pharmacological dose forms of Telmisartan and Azelnidipine. A 4.6*250mm, 5µ Inertsil ODS chromatogram was used for the analysis. A 1 ml/min flow rate was used to pump a mobile phase across the column, which contained a 70:30 ratio of phosphate buffer to acetonitrile. The temperature was kept at room temperature. For Telmisartan and Azelnidipine, the optimal wavelength was 225 nm. Telmisartan had a retention duration of 2.726 minutes and azelnidipine of 3.568 minutes. Telmisartan had a purity level of 100.25% and Azelnidipine of 98.99%. Telmisartan and azelnidipine were determined to have system suitability values of 3458.72, 2381.56, 1.13, and 1.11, respectively. Mean recovery rates of 99.59% and 100.01%, respectively, were discovered in the linearity research for Telmisartan and Azelnidipine, with correlation coefficients (r2) of 0.999 and 0.999.For repeatability, the RSD was 0.7 and for intermediate precision, it was 0.1; for both measurements, the RSD was 0.2 percent. There was accuracy, robustness, and repeatability in the precision research. The linear optical density (LOD) was 3 and the linear optical density (LOQ) was 2.98 and 10.0, respectively. This study's findings suggest that the suggested RP-HPLC technique might be effective for routinely estimating the pharmaceutical dose forms of Telmisartan and Azelnidipine, since it is straightforward, accurate, exact, sturdy, robust, quick, and repeatable.
Keywords Telmisartan, Azelnidipine, RP‐HPLC, Simultaneous estimation.
Field Medical / Pharmacy
Published In Volume 16, Issue 4, October-December 2025
Published On 2025-11-25
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