International Journal on Science and Technology

E-ISSN: 2229-7677   •   Impact Factor: 9.88

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 16 Issue 4 October-December 2025 Submit your research before last 3 days of December to publish your research paper in the issue of October-December.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 16 Issue 4
October-December 2025

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Formulation Optimization and Characterization of Etodolac Loaded Nanoemulgel: A Novel Topical Delivery Approach

Author(s) Prof. Umesh Kumar Atneriya, Ms. Kajal Shinde, Prof. Dr. Dharmendra Solanki
Country India
Abstract The topical drug delivery has a huge beneficial-effect of treating the localized pain and inflammation as it is not subject to first-pass metabolism thus the systemic side-effects are minimal. Nevertheless, poor solubility in water and low skin penetration reduce the clinical application of Etodolac (ED), which is a selective COX-2 inhibitor. The objective of this study was to test and define a nanoemulgel formulation of ED in order to increase its solubility, permeation and efficacy of treatment in a topical application. Screening of ED solubility confirmed oleic acid, Tween 80 and Transcutol P to be the best constituents in formulating nanoemulsion. Pseudo-ternary phase diagrams were used in selecting the most stable region of the emulsion component. Nanoemulsion (NE 3) was found to have the best properties among four tested systems having a small mean size, polydispersity index, high entrapment efficiency, and a highly negative value of zeta potential that proves its physical stability. This nanoemulsion was used to develop a nanoemulgel (NEG 1 to NEG 4) in a Carbopol 934 gel base that was found to NEG 3 have better spreadability, drug content (98.6 1.3%), and prolonged release of the ED in the in vitro release (96.85 % even after 12 h). Franz diffusion testing showed improved permeation through the skin (98.23 percent), and kinetics data evidenced zero order release (R2 = 0.9675) which was in support of Hixson-Crowell kinetics. During thermodynamic stressing tests NEG 3 did not break up or show signs of degradation, phase separation or recrystallization in a variety of checks. The combination overcame the intrinsic shortcomes of ED, providing a promising vehicle of successful topical anti-inflammatory treatment. Overall, NEG 3 emerged as the most effective nanoemulgel formulation for the dermal delivery of ED.
Keywords Nanoemulgel, Nanoemulsion, Etodolac, Spradability, Consistency, Phase Diagram.
Field Medical / Pharmacy
Published In Volume 16, Issue 4, October-December 2025
Published On 2025-11-30
View / Download PDF File

Share this


CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJSAT DOI prefix is
10.71097/IJSAT

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 16 Isu 3Cover Page Vol 16 Isu 2Cover Page Vol 16 Isu 1

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJSAT
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us Message on WhatsApp +91-9687-182-185 editor@ijsat.org