Anticancer Activity of Novel 2, 5- Disubstituted 1, 3, 4- Oxadiazole Derivatives

Author(s)	Ms. Baijika Patterkandy
Country	India
Abstract	1, 3, 4-oxadiazole molecule and its derivatives has become an important construction moiety for the development of novel drugs. A series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives were synthesised, by the cyclization reaction of salicylic acid hydrazide in presence of carbon disulfide and ethanol. Further it under go sulfonamide formation reaction and esterification reaction to form the derivatives. The structure was confirmed by IR, NMR spectroscopy and MASS spectrometry. Derivatives were then evaluated for their anticancer. In this OXD 5 showed good activity and OXD1, OXD2, OXD3, OXD4 showed moderate activity.
Keywords	1,3,4-oxadiazole, Derivatives, Synthesis, Charecterisation, Anticancer activity
Field	Medical / Pharmacy
Published In	Volume 16, Issue 4, October-December 2025
Published On	2025-12-03

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