International Journal on Science and Technology

E-ISSN: 2229-7677   •   Impact Factor: 9.88

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 16 Issue 4 October-December 2025 Submit your research before last 3 days of December to publish your research paper in the issue of October-December.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 16 Issue 4
October-December 2025

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

From Contaminants to Cleanse: The Role of Gut Microbes in Heavy Metal Bioremediation

Author(s) Ganiyat Opemipo Sanni, Ebizimo Oro Preyor, Oghenefejiro Oro Ighogboja, Mulikat Adeola Orenolu-Qamardeen
Country United States
Abstract Heavy metal contamination remains one of the most pressing environmental and public health challenges of the 21st century. Exposure to toxic metals such as lead (Pb), cadmium (Cd), mercury (Hg), and arsenic (As) can disrupt essential biological processes, induce oxidative stress, and damage vital organs. However, emerging evidence highlights the gut microbiome as a dynamic defense system capable of mitigating heavy metal toxicity through microbial bioremediation. This process involves the ability of specific gut microbial taxa to bind, transform, sequester, or eliminate metal ions via biosorption, bioaccumulation, methylation, reduction, and precipitation pathways. These interactions not only reduce the bioavailability of toxic metals but also help restore intestinal barrier integrity and immune homeostasis. This paper explores the intricate mechanisms by which gut microbes participate in heavy metal detoxification, emphasizing their roles in metal–microbe interactions, enzymatic transformations, and symbiotic relationships with host physiology. It also discusses how environmental exposure, diet, and antibiotics shape the composition and resilience of the gut microbiome in the face of metal stress. Furthermore, the potential application of probiotic-based bioremediation and microbiome engineering is examined as a promising strategy to enhance detoxification capacity and promote gut health. Understanding these mechanisms offers new perspectives for developing microbiome-driven therapeutics aimed at reducing heavy-metal-induced toxicity, preventing neurodevelopmental disorders, and supporting precision environmental medicine.
Keywords Gut microbiome, Heavy metals, Microbial bioremediation
Field Biology > Medical / Physiology
Published In Volume 16, Issue 4, October-December 2025
Published On 2025-12-09
DOI https://doi.org/10.71097/IJSAT.v16.i4.9827
Short DOI https://doi.org/hbf83s
View / Download PDF File

Share this


CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJSAT DOI prefix is
10.71097/IJSAT

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 16 Isu 3Cover Page Vol 16 Isu 2Cover Page Vol 16 Isu 1

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJSAT
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us Message on WhatsApp +91-9687-182-185 editor@ijsat.org